22 MAR 2013 by ideonexus
Nogo receptor 1 Key to a Plastic Mind
Formation of lasting memories is believed to rely on structural alterations at the synaptic level. We had found that increased neuronal activity down-regulates Nogo receptor-1 (NgR1) in brain regions linked to memory formation and storage, and postulated this to be required for formation of lasting memories. We now show that mice with inducible overexpression of NgR1 in forebrain neurons have normal long-term potentiation and normal 24-h memory, but severely impaired month-long memory in both...Folksonomies: memory plasticity
Folksonomies: memory plasticity
NgR1 found to be key in the formation of long-term memories.